Endocrine Abstracts

BackgroundVitamin D has shown to play a role in multiple diseases due to its skeletal and extraskeletal actions (such as immunomodulation). In this sense, vitamin D deficiency has become a worldwide health issue. Few supplementation guidelines mention calcifediol treatment, its optimal dosing and treatment duration, despite being the direct precursor of calcitriol and the biomarker of vitamin D status.Objectives<p class="abstex...

Please Development and preliminary characterization of a simple human thyroid organoid in vitro model for thyroid metabolism investigation For decades, in vitro studies of the thyroid have relied on thyroid-derived tumor cell lines, which are limited by their undifferentiated phenotype, lack of response to TSH, and chromosomal abnormalities. A viable alternative are monolayer (2D) cultures of primary thyrocytes isolated from histologically normal thyroid glan...

Background: Adrenocortical carcinoma (ACC) is one of the most aggressive endocrine malignancies. The Fibroblast Growth Factor/Fibroblast Growth Factor Receptor (FGF/FGFR) pathway plays a role in both embryogenesis and tumorigenesis of adrenal gland. Our group demonstrated that FGFR1-4 were upregulated in ACCs and that their high expression was significantly associated with worse prognosis, suggesting that they are potentially interesting therapeutic targets.<p class="abste...

Introduction: Screening for gestational diabetes (GD) in the first trimester using fasting plasma glucose (FPG) ≥92 mg/dl is routinely performed in several countries. However, evidence on the benefits and harms of early universal screening, as well as the optimal cut-off of FPG, is conflicting. This results in lack of standardised screening and treatment approaches for GD worldwide.Aims: o compare the use of pharmacological treatment and pregnancy ...

Background: Hypopituitarism is characterised by multiple pituitary hormone deficiencies causing adverse metabolic milleu and body composition changes. Aim: Our aim was to investigate the gender related differences in the prevalence of metabolic syndrome (MetS) and metabolic profiles in patients with hypopituitarism compared to obese controls. Patients and methods: A retrospective study of 282 patients with hypopituitarism (136 wome...

For the diagnosis of hyperinsulinemic hypoglycemia (HH), it is necessary that in symptomatic hypoglycemia in the fasting test the insulin/glucose ratio is >0.3, or that in spontaneous hypoglycemia there are C-peptide >0.6 nmol/l and insulin >3.0 mIU/ml. It is a well-known fact about the increasing frequency of hypoglycemia after bariatric surgery (estimated up to 30% of patients), mostly within the Dumping syndrome, but the frequency of occurrence of noninsulinoma ...

Introduction: The term “pituitary apoplexy” (PA) describes the appearance of abrupt hemorrhage and/or ischaemia of the constituents of sella turcica, usually in a pre-existing pituitary tumor. The presentation of this syndrome may be acute or subclinical.Objective: This study aims to assess clinical, imaging and hormonal features and the outcomes following surgery or conservative treatment among pituitary adenoma patients presenting with PA.</p...

Background: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD) worldwide. In clinical practice, kidney function is routinely assessed through glomerular filtration rate (GFR) estimated by equations. However, the accuracy of current equations has been questioned for people with diabetes mellitus (DM).Aim: To evaluate the performance of the European Kidney Function Consortium (EKFC), the Full Age Spectrum (FAS) and the 2021 Chronic...

Corticotrope cells give arise to utmost aggressive and to very rare pituitary neoplasias, including pituitary carcinomas, Crooke’s cell adenomas (CCA), clinically non-functioning silent corticotrope adenomas (SCA) and the Cushing-provoking pituitary adenomas (CD). The molecular etiopathogenesis of these tumors are still poorly understood. Therefore, we carried out whole exome sequencing to better understand the full genomic landscape single nucleotide variants and copy nu...

Objective: Destructive thyroiditis is the most common endocrine immune related adverse event (iRAEs) in patients treated with anti-PD1/PD-L1 agents. Given its self-limited course, current guidelines recommend no treatment for this iRAE. Nevertheless in patients with enlarged thyroid volume and a poor performance status, thyrotoxicosis may be particularly severe and harmful. Aim of the study is to evaluate if steroid treatment might be useful in improving thyrotoxicosis in subj...